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儀器設備
- 分類:體外檢測與篩選
- 發布時間:2020-08-14 00:00:00
- 訪問量:0
概要:Compound screening against a drug target whether by high-throughput screening or fragment screening is a vital step in early stage drug discovery. Biortus has an extensive collection of plate readers (detecting UV/light absorbance, fluorescence, luminescence, and scintillation) that allows development of many kinds of biochemical assays including cell-based assays. Coupled with our automated liquid handling machines, we could perform various high-throughput screening (HTS) for our clients. In addition, Biortus currently holds two other specialised screening technologies, Mobility Shift Assays (Caliper EZ Reader II, great for monitoring enzyme reactions) and Surface Plasmon Resonance (SPR, Biacore S200) for fragment screening. Below is a non-exhaustive list of assays performed in Biortus:
詳情
無論是高通量篩選還是片段篩選,針對藥物靶標的化合物篩選都是早期藥物發現中的關鍵步驟。佰翱得擁有多種功能強大的酶標儀,可以檢測紫外/可見光吸光度、熒光、化學發光和閃爍發光。以此可開發多種生化分析方法,也可用來做細胞分析。與自動化分液工作站(Aglient Bravo)相互配合,我們還可以為客戶提供各種高通量篩選(HTS)服務。 此外,佰翱得目前還擁有兩種專業的篩選技術,毛細管電遷移率分析(Caliper EZ Reader II,適用于監測酶反應)和表面等離子體共振分析(SPR,Biacore S200,用于片段篩選)。以下是Biortus的部分分析方法列表:
分析方法描述 |
檢測模式 |
儀器型號 |
特點 |
激酶分析 |
熒光 |
Caliper EZ Reader II |
|
ADP-Glo 分析 |
化學發光 |
TECAN Infinite F200 Pro/M1000
Perkin Elmer Envision 2104 |
|
鑭系金屬時間分辨熒光共振分析 |
時間分辨熒光 |
||
熒光偏振分析 |
熒光偏振 |
||
CellTiter-Glo® 化學發光分析 |
化學發光 |
||
MTT 細胞增殖及毒性分析 |
吸光度 |
||
AlphaScreen 分析 |
熒光 |
||
鄰近閃爍分析 |
閃爍熒光 |
Perkin Elmer TopCount NTX HTS |
|
表面等離子共振分析 |
光吸收位移 |
Biacore S200 |
|